of the genome is repeat-derived.
Copied DNA can make short fragments look like they belong in several places.
Disease: over 50 known repeat-expansion disorders. Personalization starts by putting the signal in the right place.20x PacBio HiFi whole-genome sequencing
Your complete genome, captured with long-read quality.
Sequence once. Own the source files. Reanalyze as genomic research, clinical databases, and AI models get better.
Standard short-read WGS is already strong for many single-base variants. PacBio HiFi adds long context for the harder questions: structural variants, repeats, phasing, and complex regions.
- 20x HiFi
- Default long-read coverage target
- Q30+
- 99.9%+ base-level accuracy with long context
- 15-25 kb
- Typical HiFi read-length range
- ~12 weeks
- Early-access turnaround target after accepted sample
Quality proof
Short-read is the baseline. HiFi is the premium source file.
The point is not that short-read WGS is bad. It is that personal health genomes are worth preserving with more context from day one.
Why context matters
Numbers, not labels.
Long reads matter when the answer depends on location, size, or which chromosome copy carries the change.
SVs in a typical genome.
Structural variants delete, duplicate, insert, invert, or move larger DNA blocks.
Disease: SVs affect about 20 million bases per person, so one event can be the main finding.CYP2D6 drug-gene alleles.
Phase shows which changes travel together on the same chromosome copy.
Drug response: CYP2D6 activity scores run from 0 to >2.25; phase and copy number can change the metabolizer call.
Side by side
Same criteria in every row.
Mass-market whole genome.
Affordable, mature, widely used. Strong for many standard small-variant calls.
Premium health source file.
Comparable base confidence with long molecules for repeats, phasing, SVs, and complex genes.
Base confidence
At least 85% Q30 basesNovaSeq-class 2 x 150 bp runs.
90% Q30+ basesMedian HiFi read accuracy is Q30+.
Context per read
Short snippets2 x 150 bp reads need computational reconstruction.
Long molecules15-20 kb reads keep neighboring variants together.
Hard clinical variants
The difficult setAJHG selected variants that short-read workflows often struggle with or send to add-on tests.
93% recovered with one HiFi genome
Structural variants
0.45 F-score
Short-read SV pipeline in medically relevant genes.
0.93 F-score
HiFi long-read pipeline in the same All of Us benchmark.
Buyer read
The efficient fileA good baseline when cost and mature pipelines matter most.
The file you want to keepMore signal for hard variants now, and more context for future reinterpretation.
Sources: Sequencing.com 30x WGS, Illumina NovaSeq X specs, PacBio Revio Q30+ specs, PacBio HiFi sequencing, Genomics Education long-read overview, repeat-content estimate, repeat-expansion review, NCBI CYP2D6 overview, AJHG difficult variant study, All of Us long-read pilot.
Bottom line:
Short-read WGS made whole genomes affordable. Greenomes is the higher-context version for people who want the strongest personal genome asset they can reasonably store today.
Sequence once. Reinterpret over time.
A better genome file gives future tools more to work with.
Greenomes stores the source material first: long molecules, phasing, structural variants, repeats, and complex regions. Then the same file can be revisited as models and databases improve.
Store the asset
Long-read context is the thing you keep.
Greenomes preserves longer molecules so future tools can see nearby sequence, phase, structural variation, repeats, and complex genes.
Why it matters
Every person carries millions of DNA differences. Future interpretation can only reread signal that exists in the file.
4-5M
DNA differences in a typical genome compared with a reference
2.1k-2.5k
structural changes, affecting about 20 million bases
~200
very rare protein-coding changes an average person carries
Population signal: 1000 Genomes, gnomAD review.
Models improve
+8.0%
+14.7%
+25.5%
Benchmarks are learning to measure biology, not trivia.
These AlphaGenome examples are model skills. They do not map to percentages of all use cases; they show better prediction of the biology that later reports can revisit.
Regulatory switches
Is this part of DNA open, active, and reachable?
Helps explain non-coding variants and disease mechanisms.
Gene activity
Which genes are likely turned up or down?
Important for pathways, dosage, biomarkers, and monitoring.
Direction of effect
Does a variant push expression higher or lower?
Closest to treatment logic: inhibit, boost, replace, or monitor.Signals: AlphaGenome Nature benchmark, GenBench, long-read population SV maps.
Revisit the genome
Interpretation gets more actionable as the field moves.
Find what matters
Re-check clinically relevant variants, SVs, repeats, paralogs, and phased variants.
Personalize care
Improve medication response, pathway, monitoring, and specialist-review hypotheses.
Design around you
Prepare for personalized peptide, protein, target, and enhancement research.
Why this is not static
The interpretation layer is moving quickly.
One stored genome can meet newer databases, models, and clinical questions later.
Long-range DNA to expression.
Proteome-wide missense effects.
DNA to RNA-seq coverage.
Genome-scale foundation model.
1 Mb sequence to regulatory effects.
Model timeline sources: Enformer, AlphaMissense, Borzoi, AlphaGenome, Evo 2.
The context test
Same genome. Very different amount of context.
A genome is not just letters. It is where those letters sit, what is nearby, and which variants travel together on the same molecule.
Selected markers
<0.1% sampled
Marker test
The premium upgrade is not more buzzwords. It is more readable source material.
Built around the source files
The long-term value of sequencing is not only the first report.
It is the file package you can keep, store, inspect, download, and reinterpret as the field improves.
Storage and export
Your genome files stay yours.
Early access includes 12 months of private vault access. Download your source files, keep them stored for future reanalysis, or take the files and be done.
- 12 months includedPrivate storage during the first year after delivery.
- Clear export pathDownload source files without being locked into the vault.
- Optional laterLong-term vault and reanalysis options are offered before the included period ends.
Your vault package includes
HiFi readsRaw long-read sequencing data
BAM or CRAMGenome reads aligned to a reference
Small variant VCFSNP and indel calls
Structural variant VCFLarger insertions, deletions, duplications, inversions, and other SVs
QC reportCoverage, quality, and sequencing metrics
Plain-English reportA readable starting summary
Three very different genomic assets.
Marker tests, Sequencing.com-style short-read WGS, and HiFi long-read WGS are not interchangeable.
Marker DNA kit
30x short-read WGS
Greenomes 20x HiFi
Primary asset
Selected markers and reports
Whole-genome short-read files
Whole-genome long-read files
Quality signal
Genotype confidence at selected sites
Run-level percent of bases at Q30+
Q30+ long reads with 15-25 kb context
Read context
Known positions only
About 150 bp reads
About 15-25 kb HiFi reads
Small variants
Only assayed markers
Strong in accessible regions
High-confidence plus phase/context
Hard variants
Mostly invisible
More limited for SVs, repeats, and paralogs
Better potential for SVs, repeats, phasing, and complex regions
Best for
Low-cost traits and ancestry
Broad, efficient WGS at mass-market cost
Premium health source files and future reanalysis
Your DNA does not need to be recollected every time the science improves. As references, AI tools, and databases advance, the same original file set can be revisited.
The first report is only version one.
How it works
One sequencing workflow. Files you can keep.
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1
Request access
Tell us what you want to sequence and how you want your files delivered.
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2
Collect your sample
We coordinate the long-read workflow with a lab partner and keep you updated from sample collection through sequencing.
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3
Receive your vault package
Early-access turnaround target is about 12 weeks after sample acceptance, followed by source files, QC, and a starting report.
Early access package
20x PacBio HiFi whole-genome vault
$1,995
Early access pricing includes sequencing coordination, raw file delivery, QC review, 12 months of private vault access, and your first report package. Expected turnaround is about 12 weeks after accepted sample.
Included:
- 20x PacBio HiFi whole-genome sequencing
- Raw reads, aligned files, variant files, and QC metrics
- Plain-English starting report
- 12 months of private vault access
- Clear file access and export controls
- Future reanalysis options
FAQ
Questions worth asking before you sequence.
What do I actually receive?
You receive your long-read source files, aligned genome files, variant files, quality metrics, and a plain-English starting report.
Why long-read instead of a cheaper DNA kit?
For health-oriented genome ownership, PacBio HiFi is the richer source file. Cheaper kits can be useful, but long reads preserve structural variants, repeats, phased variants, and complex genes that short fragments struggle to resolve.
Can I download my data?
Yes. Greenomes is designed around file access and export. The vault is meant to help you store and manage your genome files, not lock them away.
Is this medical advice?
No. Greenomes is not a diagnosis or a replacement for a physician or genetic counselor. It gives you a high-quality genome file set and a starting interpretation layer.
Why would I want this now if interpretation improves later?
Because the underlying sequence data can retain value. You can sequence once and revisit the same file set as better references, AI tools, and databases become available.
Is the 12-week turnaround guaranteed?
Our early-access target is about 12 weeks after sample acceptance. We keep you updated through collection, sequencing, QC, and file delivery.